Anticancer drugs nitrosoureas

Heterocyclic analogs of A-nitrosoureas as anticancer drugs 97CRV829. 

Kim-Triana B, Misset JL, Madelmont JC, Godeneche D, Musset M, Mathe G. Phase I trial of Perrimustine, a new cysteamine (2-chloroethyl) nitrosourea an intrapatient escalation scheme. Anticancer Drugs 1992 3(3) 225-31. 

Very few other cannabinoids have been tested (or at least reported) in animals. A-Methyllevonantradol (cf. 9) and nabilone (39) have been compared in the cat model [151]. Both cannabinoids showed dose-dependent antiemetic activity at the 20-100 mg/kg dose levels, A-methyllevonantradol being ca. 5-times more active than nabilone. The latter drug had previously been shown to suppress in the cat emesis induced by apomorphine, deslanoside and the anticancer drugs l,3-bis(2-chlorethyl)-l-nitrosourea (BCNU) and cisplatin, but not nicotine. At the doses tested (25-100/ig/kg), nabilone produced behavioural disturbances, from mild ataxia and display of pleasure at 25 /ig/kg to severe locomotor disturbance, catatonic behaviour and vocalization at 100 /ig/kg. 

Another application of IC-MS is the direct determination of fluoroacetate (compound 1080), which is a very effective rodenticide and predacide. Fluoroace-tic acid is also an intermediate metabolite of many compounds such as anticancer drugs 5-fluorouracil and 2-fluoroethyl nitrosourea. Because fluoroacetate... 

Woods, Development of nitrosourea nucleosides as anticancer agents, in "Development of Target-Oriented Anticancer Drugs", Y.C. Cheng, B. Goz, and M. Minkoff, eds.. Raven Press, New York (1983). 

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