Anticancer agents radiosensitizers

C. Anticancer Agents, Radiosensitizers, and Antiviral Agents 1. Anticancer Agents... 

One-electron reduction of misonidazole - 2-nitroimidazole radiosensitizer [891], (nitroimidazolyl)succinic esters [892] and nitroindazoles [893, 894] has been studied by ESR and polarography. Misonidazole is participated in the determination of potentiation degree of the anticancer agent cytotoxicity [891],... 

Recently Clarke et al. have advanced the proposal that antitumor RudDammine complexes may excert their action by redox cycling in the presence of oxygen and a reducing agent with formation of active oxygen species which cleave DNA. The most prominent member of the metal group is cis-DDP. Evidence for electron transfer is provided by electrochemical behavior , radiosensitization" and nephrotoxicity s 2-74, Anticancer activity is displayed by a number of other metals and metalloids in compound form s -- . The possibility exists that the ultimate active forms of the various metals may be the DNA complexes, for example, with copper s and ruthenium . ET and oxy radical formation are known to occur with enzymes that contain copper s . 

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