Antibody—toxin conjugates disulfide cross-linkers

Figure 315 The basic design of an immunotoxin conjugate consists of an antibody targeting component cross-linked to a toxin molecule. The complexation typically includes a disulfide bond between the antibody portion and the cytotoxic component of the conjugate to allow release of the toxin intracellularly. In this illustration, an intact A—B toxin protein provides the requisite disulfide, but the linkage also may be designed into the cross-linker itself.

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