Antibody riboflavin

Figure 17 Hapten 55 elicited antibodies TD1 -10E8 and TD1-36H10 that catalyze the oxidative degradation of nicotine (53) using riboflavin as a photosensitizer.

Dickerson TJ, Yamamoto N, Janda KD. Antibody-catalyzed oxidative degradation of nicotine using riboflavin. Biooi. Med. Chem. 2004 12(18) 4981-4987. 

Kumar, M., anT Axelrod, A.E. (1978). Cellular antibody synthesis in thiamin, riboflavin, biotin and folic acid-deficient rats. Proc. Soc. Exp. Biol. Med. 157 421-423. 

Panda, B. and Combs, G. F. (1963). Impaired antibody production in chicks fed diets low in vitamin A, pantothenic acid, or riboflavin. Proc. Soc. Exp. Biol, d. 113 530-534. 

Related findings were reported by Eisen and his collaborators, who showed that mouse myeloma protein, MOPC 315, which has anti-Dnp activity, also combines weakly with 5-acetyluracil, caffeine, and riboflavin, and somewhat more strongly with menadione (2-methyl-1,4-naphthaquinone) (105). None of these compounds is closely related structurally to the dinitrophenyl group. Cross-reactions with 5-acetyluracil of anti-Dnp antibodies induced in some but not all rabbits and guinea pigs were also observed (106). 

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