Antibody-neuraminidase complexes

A wide variety of crystal structure studies have been done on parts of an antibody and these have led to an overall detailed three-dimensional structure. In addition, the structures of an antibody-antigen complex (Amit et al 1986) and a neuraminidase-antibody complex (Colman et al 1987) have been determined. 

Air, G. M., Webster, R. G., Colman, P. M., and Laver, W. G., 1987, Distribution of sequence differences in influenza N9 neuraminidase of tern and whale viruses and crystallisation of the whale neuraminidase complexed with antibodies. Virology 160 346-354. 

Colman, P.M., et al. Three-dimensional structure of a complex of antibody with influenza virus neuraminidase. Nature 326 358-363, 1987. 

Colman PM, Tulip WR, Varghese JN, Tulloch PA, Baker AT, Laver WG, Air GM, Webster RG. Three-dimensional structures of influenza virus neuraminidase-antibody complexes. Philos Trans R Soc Lond, B Biol Sci 1989 323 511-518. 

Tulip WR, Varghese JN, Webster RG, Laver WG, Colman PM. Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface. J Mol Biol 1992 227 149-159. 

The three-dimensional structures of approximately 30 complexes between antibodies and various protein antigens have been determined in recent years, including hen egg white lysozyme (HEL) (Amit et al., 1986 Sheriff ct a/., 1987 Padlaneta/., 1989 Chitarra et a/., 1993 Braden eta/., 1994 Rondo et al., 1999 Li et al., 2000), influenza virus neuraminidase (Colman et al., 1987 Tuhp et al., 1992 Malby et al., 1994), horse cytochrome c (Mylvaganam et al., 1998), human tissue factor (Huang et al.,... 

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