Antibody Cross-Reactivity and Molecular Mimicry

TEL His-121 makes only one hydrogen bond to the antibody light chain and induces a peptide flip between residues VlW92 and VlS93, a conformational change that is likely responsible for the slower on-rate of the interaction (Fig. 1C). 

Intermolecular Contacts in the FvD1.3-FvE5.2 and F vDL3-FIEL Complexes  

Atom pairs in the FvDl.3- FvE5.2 compl ex that mimic hydrogen bonds in the FvD1.3-HEL complex are in boldface type.  

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