Antibiotics - sulphonamides

SULPHONAMIDES ANAESTHETICS - GENERAL t effect of thiopentone but duration of action shortened Uncertain possibly displacement from protein-binding sites Be aware that a smaller dose may be needed 

SULFADIAZINE LIDOCAINE SOLUTIONS Precipitation of drugs, which may not be immediately apparent A pharmaceutical interaction Do not mix in the same infusion or syringe 

SULPHONAMIDES PRILOCAINE Risk of methaemoglobinaemia there is a case report of methaemoglobinaemia with topical prilocaine in a patient taking sulphonamides Additive effect Avoid co-administration 

SULPHONAMIDES Secondary drug ANTIARRHYTHMICS Effect Mechanism Precautions 

CO-TRIMOXAZOLE AMIODARONE Risk of ventricular arrhythmias Uncertain Avoid co-administration 

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ANTIBIOTICS- SULPHONAMIDES, TRIMETHOPRIM ANTIMALARIALS -PYRIMETHAMINE T antifolate effect Additive effect Monitor FBC closely the effect may take a number of weeks to occur... 

METHENAMINE ANTIBIOTICS - SULPHONAMIDES- SULFADIAZINE Risk of crystalluria Methenamine is only effective at a low pH, and this is achieved by acidifiers in the formulation. Sulfadiazine crystallizes in an acid environment Avoid co-administration... 

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