Antibiotics binding site probing

These innovative molecules can be of great use as probes of DNA structure and as artificial or synthetic restriction endonucleases by cutting at very specific sites. The cleavage of chromatin and the mapping of antibiotic sites are just some of the uses explored for these complexes [154, 159—161]. Thus, the preferential binding of the antibiotic netropsin to restriction fragments was shown to be at AT-rich regions. 

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