Antibacterials anthracycline

Himalomycin A 263and B 264, two new anthracycline antibiotics, were isolated from the culture broth of the marine Streptomyces sp/ isolate B6921, and both exhibited strong antibacterial activity but no anti-algal activity against the tested micro-algae. 

Further antibiotics, mainly derived from actinomycetes, are used for special applications in human and veterinary medicine [20]. These compounds have numerous chemical structures. The macrolides, tetracyclines, aminoglycosides, glycopeptides, and ansamycins for instance are used in antibacterial treatment whereas the anthracyclines reached the market to supplement anticancer chemotherapy. The fairly toxic polyether-type antibiotics are preferably used as anticoccidial agents. Due to the dramatically increasing resistance of clinical important bacterial strains new targets for the discovery of novel types of antibacterial agents are urgently needed. 

Anthracyclines glycosylated at the 4-position are very rarely mentioned in the literature, and 4-0-(/l-D-glucopyranosyl)-fi-rhodomycinone (39a) isolated from a mutant of Actinomadura roseoviolacea was the first one of this series. It exhibited no antibacterial or cytotoxic activity [66]. However, its glucuronic acid derivative histomodulin (39b), isolated from Streptomyces ruber JCM3131, was reported as an up-regulator of MHC class-I molecules in B16/BL6 cells [67]. 

C28H30O13 574.537 Anthracycline antibiotic, Isol. from Streptomyces steffisburgensis, Strepto-myces elgreteus and Actinoplanes utahensis. Antibacterial and antineo-plastic agent. Orange-yellow cryst. 

Anthracyclines, 25.533 Antiallergic drugs, ocular treatment, 11.420 Antibacterial drugs, resistance, 31.413, 32.445 intrapartum, 32.446 Anticancer antimetabolites, 29.531 Anticholinergic drugs, 22.507, 31.273 cardiovascular risks, 32.318 Anticoagulants, oral, skin necrosis, 29.358... 

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