Antibacterial drugs protein synthesis inhibitors

The ability of streptomycin, under certain conditions, to induce misreading of the genetic code and to produce nonsense polypeptides, may be phenomena of the laboratory unrelated to the clinical use of this drug (Luzzatto, Apirion, and Schlessinger, 1968). Streptomycin is lethal to cells only when they are vigorously engaged in protein synthesis. For this reason, some other inhibitors of protein synthesis, notably chloramphenicol and tetracycline, interfere with the antibacterial action of streptomycin. 

---