Antianxiety molecules

Benzimidazole is an important heterocyclic nucleus in the field of medicinal chemistry. The most prominent benzimidazole compound in nature is N-ribosyldimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. The versatile nature of benzimidazole makes it a highly explored molecule in medicinal chemistry. A number of pharmacological activities are associated with benzimidazole derivatives such as anthelmintic, antiulcer, antipsychotic, proton pump inhibitor, antianxiety, anti-emetic and sedative, vasodilator, anticancer, analgesic, antihistaminic, antifungal, antiviral and antimicrobial. 

Opipramol (Ensidon). In an effort to impart antianxiety properties to the imipramine molecule, Schindler and Blattner (94) incorporated the perphenazine side chain (piperazinoethanol) into the unsaturated form (iminostilbene) of imipramine ... 

Bruce and co-workers furthermore used the photochemical acylation for the synthesis of the benzodiazepine skeleton (Scheme 53). Benzodiazepines (e.g., diazepam [Valium]) are widely used as antianxiety agents, which makes them attractive target molecules. Transformation of 6 (R = Ph) into its bis-triflate (149) and subsequent reaction with N-methylethylenediamine afforded the diazepine 148. The conversion of the remaining triflate into either nitriles or esters was subsequently accomplished using suitable organopalladium compounds. ... 

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