Anti-viral drug screening

The traditional method for determining anti-viral drug activity involves conducting a plaque assay. A preliminary mass based screening can be helpful in reducing the number of drug candidates that need to be screened by more... 

A search for a specific inhibitor of the action of RNA replicase (RNA dependent RNA polymerase) another point at which viral replication could be inhibited independently of host cell metabolism, led to the screening of KXX) compounds against bacteriophage Q/S RNA replicase with E. coli as host cell. Thirty active compounds were obtained of which (LXIV) was the most active. This inhibited phage multiplication in E. coli by 99 per cent compared with control at 10 pg/ml whereas host cell growth was only inhibited by 50 per cent [243]. These authors hopefully conclude thus, further studies may produce a universal anti-RNA virus drug without side effects . 

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