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Anti-synthetase syndrome

Many myositis-specific antibodies are reported in PM/DM, with anti-aminoacyl-tRNA synthetases, the most frequent (Table 3) (223,236). ILD and the presence of anti-synthetase antibodies are strongly associated. Anti-Jo 1 antibodies, which occur most commonly, are found in 30% to 100% of cases with ILD, but in 0% to 37% of other PM/DM patients (28,224,233—235,237—241). The anti-synthetase syndrome (1,2,223,225,236) consists of an association between anti-synthetase antibodies and, in a variable proportion of cases, myositis, fever, arthritis, Raynaud s phenomenon, mechanic s hands, and ILD, which is present in 75% to 89% of cases (28,224,233—235,237—241). The anti-Mi2 antibody, usually found in DM, is also associated with ILD, whereas the anti-SRP antibody is generally not (236). Anti-Jol antibodies are more frequent in PM, whereas non-anti-Jol antibodies are more common in DM, and especially in patients with ILD and CADM (236,242—246). Anti-synthetase antibodies are also reported in IPF (28). [Pg.454]

Myositis-associated antibodies occur also in other CTDs or overlap syndromes (discussed later), which raises nosological issues (Table 3). The anti-Ro/SS-A antibody has been associated with the anti-synthetase syndrome. [Pg.454]

Plastiras SC, Soliotis FC, Vlachoyiannopoulos P, et al. Interstitial lung disease in a patient with anti synthetase syndrome and no myositis. Clin Rheumatol 2007 26(1) 108-111. [Pg.503]

Anti-tRNA synthetases Aminoacyl-tRNA-synthetase Antisynthetase syndrome Si... [Pg.455]


See other pages where Anti-synthetase syndrome is mentioned: [Pg.302]    [Pg.337]    [Pg.11]   
See also in sourсe #XX -- [ Pg.454 , Pg.497 ]




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