Anti-asthmatic agents

The 2-aminooxazole analogue, isamoxole (74), is an anti asthmatic agent. Its synthesis follows the classic pattern of condensation of hydroxy acetone with ji-propylcyanamide to establish the heterocyclic ring (21) The synthesis of isamoxole (74)... 

Respiratory system Anti-asthmatic agents 2 Montelukast 61... 

Anticonvulsants - [ANTI ASTHMATIC AGENTS] (Vol 2) - [HYPNOTICS, SEDATIVES, ANTICONVULSANTS, AND ANXIOLYTICS] (Vol 13) -organobromines as [BROMINE COMPOUNDS] (Vol 4) -sex hormones or [HORMONES - SEX HORMONES] (Vol 13) -use ofbromides [BROMINE COMPOUNDS] (Vol 4)... 

C24 H3oF306 Anti-inflammatory Anti-asthmatic agent Glucocorticoid Topical cream and solution Otic drops Intravitreal implant 67-73-2 April 1982/ Fougera G and W Labs Medics Taro Bausch and Lomb Hill Dermac Galderma Labs LP... 

This then was the background to the beginning of our medicinal chemistry approach to the identification of an orally effective anti-asthmatic agent, which began around 1969-1970. 

It was time for our first major re-think. Basically we had shown that our general medicinal chemistry approach to oral activity had been successful. These more lipophilic chromones were indeed being absorbed from the gastro-intestinal tract and reaching their required site of action, but we concluded that one could not use the rat PCA test, or indeed any of our newly developed tests, in a quantitatively predictive sense, for the identification of compounds which would be active anti-asthmatic agents, of the cromolyn type, in humans. I suspect that others have more recently come to the same conclusion about the PCA test, following the clinical evaluation of their own selected compounds. 

Marine Algae as Potential Anti-Asthmatic Agents... 

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