Anthracycline Analogs

One of the most common applications of VCD is the AC determinations of chiral compounds. Two recent studies on anthracycline analogs and on pentacoordinate phosphorus complexes from our group are included below as examples. 

Fig. 3 The structures of the three anthracycline analogs studied. Adapted with permission from [21]. Copyright (2010) Wiley...

Weiss, R. B.,Sarosy G., Clagett-Carr, K., Russo, M., Leyland-Jones,B. Anthracycline analogs the past, present, and future. Cancer Chemother. Pharmacol. 1986, 18, 185. 

Natural anthracycline analogs isolated from Streptomyces sp. often contain two or more sugars connected by axial (l->4) linkage. The anthracycline disaccharides or oligosaccharides invariably possess amino sugar as the first moiety attached to the aglycon (38,56). For instance, daunosaminyl daunorubicin (Figure 6), which is isolated from fermentation, contains two... 

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