Fosinopril Antacids

ACE INHIBITORS ANTACIDS 1 effect, particularly of captopril, fosinopril and enalapril 1 absorption due to t in gastric pH Watch for poor response to ACE inhibitors... 

An aluminium/magnesium hydroxide antacid reduced the bioavailability of captopril by 40%, but this did not seem to be clinically important The bioavailability of fosinopril was reduced by about one-third by Mylanta. An antacid did not affect ramipril pharmacokinetics. 

However, with fosinopril, the manufacturers suggest separating administration of antacids by at least 2 hours. 

Moore L, Kramer A, SwitesB, Kramer P, Tu J. Effect of cimetidine and antacid on the kinetics of the active diacid of fosinopril in healthy subjects. J Clin Pharmacol (1988) 28, 946. 

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