Captopril Antacids

Drugs that may be affected by antacids include allopurinol, amphetamines, benzodiazepines, captopril, chloroquine, corticosteroids, dicumarol, diflunisal, digoxin, ethambutol, flecainide, fluoroquinolones, histamine H2 antagonists,... 

ACE INHIBITORS ANTACIDS 1 effect, particularly of captopril, fosinopril and enalapril 1 absorption due to t in gastric pH Watch for poor response to ACE inhibitors... 

An aluminium/magnesium hydroxide antacid reduced the bioavailability of captopril by 40%, but this did not seem to be clinically important The bioavailability of fosinopril was reduced by about one-third by Mylanta. An antacid did not affect ramipril pharmacokinetics. 

In 10 healthy subjects an antacid containing aluminium/magnesium hydroxide and magnesium carbonate reduced the AUC of a single 50-mg dose of captopril by about 40%, when compared with the fasting state. However, this did not alter the extent of the reduction in blood pressure. ... 

Note that greater decreases in captopril bioavailability (caused by food , (p.26)) were found not to be clinically relevant, therefore, it is unlikely the change seen with antacids will be clinically important. 

Mantyla R, Mannisto PT, Vuorela A, Sundberg S, Ottoila P. Impairment of captopril bioavailability 1 concomitant food and antacid intake. IntJ Clin Pharmacol Ther Toxicol (1984) 22,... 

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