Another Independently Developed PXR Null Mouse Line

3 Another Independently Developed PXR Null Mouse Line 

Also in this study, cotreatment with the PXR ligand PCN dramatically decreased the liver damage caused by LCA. However, treatment with PCN did not reverse the LCA toxicity in the PXR null mice. These results suggest a protective role of PXR in LCA toxicity [10], 

---