Annonaceae biological activities

A wide variety of natural products has been isolated from the Annonaceae. However, the report in 1982 of the isolation of the acetogenin uvaricin (1) from Uvaria accuminate was the first example of what is now a large and growing series of acetogenins found in these sources. More than one-hundred examples have been reported in the intervening decade.3- That these compounds often exhibit remarkably potent cytotoxic and other biological activity has fueled interest in this class. 

The Annonaceae have been found to be a good source of interesting, biologically-active compounds (e.g. acetogenins) and we have already been given further examples in this symposium. 

Alkaloids of the Annonaceae Occurrence and a Compilation of Their Biological Activities... 

The data are organized in alphabetical order of alkaloid names, skeleton type, number of substance, with a list of botanical species from which they were isolated as well as the part of plant, geographical distribution, and references. These data are shown in Table 3. The biological activities reported for this type of alkaloid are shown in Table 4, organized by the alkaloid name, followed by the type of activity reported. The present compilation includes data from most of the papers published between 1929 and 2012. Among the 934 alkaloids described in the literature during this period, about 99 alkaloids isolated from Annonaceae species have shown biological activities. 

Table 4 Biological activities related to alkaloids from annonaceae in the literature between 1929 and 2009 ... 

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