Animal models parenteral dosing

MK-0911 has shown activity in animal models following intravenous, intraperitoneal, and oral administration. However, the oral route requires doses higher by as much as 300-fold than the parenteral routes... 

Whole animal studies are generally necessary to determine the effect of the drug on organ systems and disease models. Cardiovascular and renal function studies of all new drugs are generally first performed in normal animals. Where appropriate, studies on disease models are performed. For a candidate antihypertensive drug, animals with hypertension would be treated to see whether blood pressure was lowered in a dose-related manner and to characterize other effects of the compound. Evidence would be collected on duration of action and efficacy after oral and parenteral administration. 

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