Animal models cont

TABLE 12.14 Selected Experimental Animal Model Data in Support of Lead Neuroepidemiological Findings—(cont.) ... 

TABLE 12.15 Illustrative Multisystem Toxicological Mechanisms for Lead Effects Relevant to CNS of Humans and Animal Models of Lead Toxicity In Vitro and In Vivo Studies—(cont.)... 

D.T. Hill and C. Barth. A dynamic model for stimulation of animal waste digestion. Wat. Poll. Cont. Ass., 10 2129-2143, 1977. 

Figure 7 Mean infection scores of P. ctm nti cysts in homogenates of lung tissues in our four-day cyst reduction model (41). Immunosuppressed rats were allowed to develop heavy P. carinii infections, they were treated with LY303366 for up to 4 days, and the numbers of cysts in the lungs were counted microscopically. Treatment groups were A, animah receiving a single 10 mg IV dose 4 days prior to necropsy B, animals receiving a single 5 mg/kg IV dose 4 days prior and daily 5 mg/kg oral doses on days 1—4 prior to necropsy C, animals receiving daily oral doses on days 1-4 prior to necropsy. Infected control (Inf. cont.) animals received no therapy for P. carinii pneumonia.

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