Animal cell lines growth kinetics

Kinetics models for cell growth and death, as well as for substrate consumption and product and byproduct synthesis, are presented here. Most of these were developed for hybridomas in continuous processes. Although these models are representative of animal cell systems, it is important to understand that the cellular response to an environmental stimulus is highly dependent on the specific cell line. The review published by Porter and Schafer (1996) illustrated this variability through the comparison of experimental data and models from different groups of cell lines. Besides this, the lack of proper knowledge to explain experimentally observed phenomena also accounts for the variability of model structures. 

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