Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Anhydro sugars, preparation esters

K. Bock and C. Pedersen, Reaction of sugar esters with hydrogen fluoride. 13. Preparation of l,6-anhydro-/S-D-gulopyranose derivatives, Acta Chem. Scand., Ser. B, 29 (1975) 181-184. [Pg.176]

In order to preserve optimal stability in the hybridization of RNA by sugar-modified oligonucleotides, nucleosides substituted at the 2 -position must retain a C3 -endo puckered conformation. To this end, the 2 -0- 2-[iV,N-(dimethylamino)oxy]ethyl and the 2 -0- 2-[Ar,lV-(diethylamino)oxy]-ethyl 3 -phosphoramidite derivatives of thymidine (38a, 38b) have been synthesised. The nucleoside precursors were prepared from a phthalimido-derivative obtained from 2,2 -anhydro-5-methyluridine which had been treated, after appropriate protection, with a borate ester generated in situ and then reacted with PPha, DEAD and AT-hydroxyphthalimide. The incorporation of (38a) and (38b) in oligonucleotides and oligodeoxynucleotides resulted in high binding affinity for... [Pg.170]

See other pages where Anhydro sugars, preparation esters is mentioned: [Pg.58]    [Pg.74]    [Pg.6]    [Pg.191]    [Pg.1061]    [Pg.41]    [Pg.57]    [Pg.378]    [Pg.390]    [Pg.47]    [Pg.57]    [Pg.123]    [Pg.174]    [Pg.62]    [Pg.297]    [Pg.2081]    [Pg.40]    [Pg.140]    [Pg.180]    [Pg.150]    [Pg.42]    [Pg.60]    [Pg.197]    [Pg.52]   
See also in sourсe #XX -- [ Pg.47 ]



SEARCH



1.6- anhydro preparation

Anhydro sugars

Anhydro sugars preparation

Esters preparation

Sugar esters

© 2024 chempedia.info