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Angiotensin generation

A parallel system for angiotensin generation exists in several other tissues (eg, heart) and may be responsible for trophic changes such as cardiac hypertrophy. The converting enzyme involved in tissue angiotensin II synthesis is also inhibited by ACE inhibitors. [Pg.239]

Klickstein L, Wintroub B. Separation of angiotensins and assay of angiotensin-generating enzymes by high-performance liquid chromatography. Anal Biochem 1982 120 146-50. [Pg.2046]

Angiotensin converting enzyme (ACE) plays a central role in cardiovascular hemostasis. Its major function is the generation of angiotensin (ANG) II from ANGI and the degradation of bradykinin. Both peptides have profound impact on the cardiovascular system and beyond. ACE inhibitors are used to decrease blood pressure in hypertensive patients, to improve cardiac function, and to reduce work load of the heart in patients with cardiac failure. [Pg.9]

In some patients with hypertension and in all patients with cardiac failure, the renin-angiotensin system is activated to an undesired degree, burdening the heart. The consequences of diminished ANG II generation by ACE inhibitors are multiple. In patients with hypertension, blood pressure is reduced as a result... [Pg.9]

The renin-angiotensin-aldosterone system (RAAS) generates the peptide hormone angiotensin II and subsequently the mineralocorticoid aldosterone, which both exert considerable impact on blood pressure ( blood pressure control) and fluid homeostasis, and... [Pg.1066]

In the zona glomemlosa of the adrenal gland, renin is locally synthesized, and together with angiotensinogen and ACE generates angiotensin II, which acts as... [Pg.1067]

Chymostatin-sensitive Il-generating enzyme Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction Trial Collaborative Study Captopril Trial ( The Effect of Angiotensin-Converting Enzyme Inhibition on Diabetic Nephropathy ) calcium channel blocking agents Candesartan in Heart Failure Assessment of Reduction in Morbidity and Mortality Trial congestive heart failure, but the latest recommendations use HF for heart failure chronic kidney disease cardiac output... [Pg.31]

Petrie MC, Padmanaban N, McDonald JE, Hillier C, Connell JMC, McMur-ray J J V. Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteres from patients with heart failure and coronary heart disease. J Am Coll Cardiol 2001 37 1056-1061. [Pg.263]

This enzyme [EC 3.4.23.15], also known as angiotensinforming enzyme and angiotensinogenase, catalyzes the hydrolysis of the Leu—Leu bond in angiotensinogen to generate angiotensin I. It belongs to the peptidase family Al. [Pg.616]

See other pages where Angiotensin generation is mentioned: [Pg.1068]    [Pg.1068]    [Pg.355]    [Pg.1068]    [Pg.1068]    [Pg.355]    [Pg.171]    [Pg.213]    [Pg.328]    [Pg.273]    [Pg.1066]    [Pg.1067]    [Pg.1067]    [Pg.1067]    [Pg.1067]    [Pg.1068]    [Pg.1068]    [Pg.1142]    [Pg.130]    [Pg.169]    [Pg.67]    [Pg.100]    [Pg.244]    [Pg.25]    [Pg.358]    [Pg.254]    [Pg.726]    [Pg.728]    [Pg.190]    [Pg.132]    [Pg.8]    [Pg.42]    [Pg.294]    [Pg.352]    [Pg.164]    [Pg.21]    [Pg.275]    [Pg.279]    [Pg.279]    [Pg.143]    [Pg.522]    [Pg.35]    [Pg.44]    [Pg.45]   
See also in sourсe #XX -- [ Pg.2043 ]



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