Anemia, pernicious

One aspect of vitamin B12 deficiency is that it results in the accumulation of W5-methyl-THF. N5-Methyl-THF is synthesized in mammals by an irreversible reaction (as shown above) if it cannot be utilized because of a deficiency of vitamin B12, then it accumulates. This causes a depletion of the other forms of THF, resulting in a deficiency of THF. Megaloblastic anemia (pernicious anemia) is associated with a deficiency of cobalamin... 

C (ascorbic acid) 5 -Deoxyadenosyl cobalamin Transfer of methyl groups intramolecular rearrangements Antioxidant Anemia, pernicious anemia, methylmalonic acidosis Scurvy (swollen and bleeding gums, subdermal hemorrhages)... 

Other associated comorbidities, which predispose to Salmonellosis are sickle cell anemia, pernicious anemia due to achlorhydria, postoperative stomach due to hypochlorydria, reduced motility of gastrointestinal tract due to a variety of conditions, promoting reduced stasis of intestinal contents and bacterial overgrowth. 

Megaloblastic anemia (pernicious anaemia) results from a deficiency of cobalamin and THF. 

Also see ANEMIA, PERNICIOUS DIGESTION AND ABSORPTION, section on "Stomach.")... 

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