Ancistrocladus korupensis Michellamines

The dimeric stereoisomer alkaloids michellamines A, B and C (38) were obtained From the liane Ancistrocladus korupensis (Ancistrocladaceae). On the basis of their structural similarity to other PKC inhibitors, they have been studied for this activity. Michellamines inhibited rat brain PKC, with IC50 values in the 15-35 pM range. Michellamine B was a non-competitive PKC inhibitor with respect to ATP, whereas mixed-type inhibition was observed when the peptide concentration varied. The results indicate that the dimeric alkaloids bind to the PKC kinase domain and not to its regulatory domain. All three michellamines blocked both the ATP and the... 

G., and Boyd, M. R. (1997) Michellamines D-F, new HlV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis. J Nat Prod. 60, 677-683. 

NaphthvlisoQuinoline Michellamines A, B (33), C Ancistrocladus korupensis HIV HIV-induced cell killing HIV-RT [35. 36]... 

Boyd MR, HaUock YF, Manfredi KP, Blunt JW, McMahtm JB, Buckheit RW, et al. Anti-HIV michellamines from Ancistrocladus Korupensis. J Med Chem 1994 37 (12) 1740 5. 

Michellamine B (19), from Ancistrocladus korupensis (formerly considered to be /4. abbreviatus) has been shown to possess potent activity against HIV-1 and HIV-2 (Manfredi et al., 1991 Thomas and Gereau, 1993). 

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