Anaphylaxis alteplase

Rudolf J, Grond M, Prince WS, SchmuUing S, Heiss WD. Evidence of anaphylaxy after alteplase infusion. Stroke 1999 30(5) 1142-3. 

Because of his history of strep infection, alteplase carries a high risk of anaphylaxis Because of his history of strep infection, streptokinase will be less effective than would otherwise be expected... 

Immunologic A patient experienced anaphylaxis after an initial bolus and subsequent delayed infusion of alteplase for thrombolysis of acute ischaemic stroke. Although rare, anaphylaxis is a recognized adverse event with alteplase administration, and infusion should be ceased following any symptoms of an anaphylactic reaction to avoid a dose-dependent major reaction [34 ]. 

Cheng JN, Lee A, Jannes J, Heddle RJ, Koblar SA. A patient with anaphylaxis after alteplase infusion. J Clin Neurosci 2012 19(2) 314-5. Martinez-Ramirez S, Delgado-Mederos R, Marin R, Suarez-Calvet M, Sainz MP, Alejaldre A, et al. Statin pretreatment may increase the risk of symptomatic intracranial haemorrhage in thrombolysis for ischemic stroke results from a case-control study and a meta-analysis. J Neurol 2012 259(l) lll-8. 

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