Analysis of Natural Products versus Drugs and Synthetics

Chirality Analysis of Natural Products versus Drugs and Synthetics 

Source Synthetic Drugs DNP Plantea Subgroups DNP Monera 

The stereo index, as shown in Fig. 3.3 is the coefficient between the number of stereo centers and the number of non-H atoms. While there are completely achiral natural products, natural products with a low stereo index, meaning that there are at least 27 non-H atoms, are very uncommon. A possible explanation might be that natural products often contain highly substituted or fused ring systems. If these rings are aromatic, they contain no chiral centers at all, if these rings are non-aromatic there will likely be more than one chiral center. 

Determination of the Reiative and Absoiute Stereochemistry of Naturai Products 

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