Analysis of Morphine Alkaloids

FIGURE 5,17 Chemical diagram of derivatives of codeine and codeinone alkaloids. 

FIGURE 5.18 Chemical diagram of corresponding barbituric (R=0) and thiobarbituric (R=S) derivatives. 

FIGURE 5.19 Crystal structures of 6-O-acetylcodeine and N-methylcodeinium iodide. 

FIGURE 5.20 (a) The molecular structures of the barbituric aud thiobarbituric derivatives with their displacemeut ellipsoids drawu at the 50% probability level (b) liukage of the molecules and (c) the dihedral angles between the mean planes of the A/B/C and D/E rings. 

FIGURE 5.21 IR spectra of (1) codeine N-oxide, (2) N-methylcodeinimn iodide, (3) 6-0-acetylcodeine, (4) barbituric, and (5) thiobarbituric derivatives. 

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