Analysis Between the Different CYP Crystal Structures

Comparative Analysis Between the Different CYP Crystal Structures 

CYP2C9 was the first human cytochrome P450 that was crystallized on the basis of the CYP2C5 experience. Nevertheless, the construct in this initial crystal structure 

There are six crystal structures reported in the Protein Data Bank two without ligand (ltqnand IwOe), one cocrystallized with progesterone (7) (IwOf), one with mytrapone (8) (IwOg), one with ketoconazole (9) (2j0c) and one with erythromycin (10) (2j0d). 

The analysis of the cytochrome crystal structures reveals extensive differences among the mammalian and the human CYPs that may reflect the structural flexibility of these enzymes and therefore the broad substrate specificity observed. In general, the secondary elements and the overall structure of the CYP are conserved. Nevertheless, it seems that in most enzymes, the most flexible regions are located between the F-G helixes and the B-C loop. For example in the CYP2B4 apoprotein (lpo5) the 

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