Anaesthetics, general Opioids

CNS depressants + CNS depressants Alcohol + Antihistamines Ben KJiazepines + Anaesthetics, general Opioids + Benzodia pines Impaired psychomotor skills, reduced alertness, drowsiness, stupor, respiratory depression, coma, death... 

Drugs that stimulate respiration (analeptics) have a place in anaesthetic practice but are not a substitute for mechanical ventilation. They have a direct effect on respiratory drive they do not share a common molecular structure. Respiratory stimulation is generally better achieved by antagonising the depressant effects of the depressant drug, e.g. flumazenil for benzodiazepines naloxone for opioids. 

Psychotropic drugs neuroleptics potentiate or synergise with opioids, hypnotics and general anaesthetics. 

Resumption of car driving or other skilled activity after anaesthesia is a special case, and an extremely variable one, but where a sedative (e.g. i.v. benzodiazepine, opioid or neuroleptic), or any general anaesthetic has been used it seems reasonable not to drive for 24 h at least. 

RECEPTOR ANTAGONIST (channel-blocking at NMDA receptors). It is an OPIOID ANALGESIC, (dissociate) GENERAL ANAESTHETIC, PSYCHOTROPIC and ANTICONVULSANT. It iS a drug of abuse and has been withdrawn from human clinical use. etidocaine [ban, inn, usan] (Duranest ) is an amide series LOCAL ANAESTHETIC, used by injection for infiltration and regional pain relief. 

However, opioid analgesics cause respiratory and cardiovascular depression, which is additive to that of general anaesthetics. 

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