Anticholinesterases General anaesthetics

Some inhalational anaesthetics can impair the effect of anticholinesterases on neuromuscular blockers (see Anaesthetics, general + Anticholinesterases , p.93). 

Interestingly, anticholinesterases, ACH and ion antagonize competitively pancuronium bromide effectively however, its activity is virtually enhanced by general anaesthetics, for instance halothane, ether, enflurane etc. (see Chapter 4). Therefore, the latter substantial potentiation in pharmacological activity is particularly useful to the anaesthetist due to the faet that it is administered invariably as an adjunct to the anaesthetic procedure in order to cause simultaneous relaxation of the skeletal muscle. 

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