Acids anacardic

During the past four decades phenolic resins have become of increased significance in rubber compounding. For example, the resin based on cashew nut shell liquid, which contains phenolic bodies such as anacardic acid (Figure 23.23), may, when blended with hexamine, be incorporated into nitrile rubber (butadiene-acrylonitrile rubber). 

Anacardium occidentalle L. Cashew nut shell Anacardic acid, Cardanol, Brazil, Tanzania, Kenya, Nigeria... 

The structures of anacardic acid, cardol, cardanol, and 2-methyl cardol are given in Fig. 9. Each component... 

Anacardic acid Anacardium occidentalle L Anisoxide Star anise oil... 

Several small molecule modulators (SMM) of p300 and PCAF have been developed (Varier et al, 2004). Recently, the first naturally occurring HAT inhibitor anacardic acid was isolated from cashew nut shell liquid, which inhibits the HAT activity of both p300 and PCAF very effectively (Balasubramanyam et al, 2003). By using anacardic acid as a synthon, an amide derivative of anacardic acid, CTPB, has been synthesized, which is the only known small molecule activator of any histone acetyltransferase, in this case, p300. However, cells are impermeable or... 

Castillo-Juarez 1, Rivero-Cruz F, Celis H. (2007) Anti-Helicobacter pylori activity of anacardic acids from Amphipterygium adstringens. J Ethnopharmacol 114 12-11. 

Figure 11.2 Di-substrate analogs Lys-CoA 1, H3-CoA-20 2, the natural product anacardic acid 3, its analogs cyano-benzamides 5 and 6 and the p300 activator CTPB 4.

Contradictory results were obtained from studies with berKamide analogs of anacardic acid. While CTPB 4 (Figure 11.2) was reported to be an activator of p300 [13], the related cyano-benzamides S and 6 (Figure 11.2) aded as cell-permeable inhibitors of p300, exhibiting a similar profile to anacardic acid [15]. 

Figure 11.3 Anacardic acid analog 7, y-butyrolactone MB-3 8, isothiazolones CCT077791 9 and CCT077792 10 and the quinolines n, 12 and 13.

Figure 11.3) was shown to be 10-fold more potent than the first generation inhibitors and anacardic acid, but less potent than MB-3 [20]. 

Sun, Y.L., Jiang, X.F., Chen, S.J. and Price, B.D. (2006) Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Letters, 580, 4353 356. 

Souto, J.A., Conte, M., Alvarez, R., Nebbioso, A., Carafa, V., Altucci, L. et al. (2008) Synthesis ofbenzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities. ChemMedChem, 3, 1435-1442. 

The 22 1 co5 anacardic acid (6-alkylsalicylic acid) of insect- and mite-resistant geranium... 

Chelikani R, Kim Y, Yoon D-Y et al (2009) Enzymatic polymerization of natural anacardic acid and antibiofouling effects of polyanacardic Acid Coatings. Appl Biochem Biotechnol 157 263-277... 

Anacardic acids Anacardium occidentak (cashew) COX (PGS) [antitumour,... 

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