Amyotrophic lateral sclerosis overexpression

Kong, J. and Xu, Z. Overexpression of neurofilament subunit NF-L and NF-H extends survival of a mouse model for amyotrophic lateral sclerosis. Neurosci. Lett. 281 72-74,... 

In the brain, S100A6 is restricted to some subpopulations of neurons and astrocytes (Yamashita et al., 1999). Interestingly, S100A6 is overexpressed in astrocytes associated with the neurodegenerative lesions of amyotrophic lateral sclerosis (ALS) (Hoyaux et al., 2002) as well as in patients with Alzheimer s disease (AD), and in two different AD mouse models (Boom et al., 2004). A deregulation of S100A6 expression was also found in certain tumour tissues (Stulik et al., 2000 Luu et al., 2005 Hancq et al., 2004b Cross et al., 2005) and in patients with acute myeloid leukemia (Murphy et al., 1988). 

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