Amphiphilic polymers with derivatives

Linear amphiphilic polymers with carboxyl groups were also available via sequential cationic polymerization of a fimctional vinyl ether and an alkyl derivative [6]. The sequential living cationic polymerization of diethyl 2-(vinyloxy)ethylmalonate [VOEM CHf=CHOCH2CH2CH(COOCH2CH3)2]... 

Naka K., Nakamura T., Okhi A., Maeda S. Aggregates of amphiphilic block copolymers derived from poly((A-acylimido)ethylene) and their complexes with lipase in water. Polymer J. 1995 27(11) 1071-1078. 

In recent years, there have been significant developments in the field of living carbocationic polymerization (LCCP) of vinyl monomers, such as isobutylene (IB), styrene and its derivatives, and vinyl ethers, leading to a wide variety of functional polymers (for recent reviews see Refs. 1-4). Due to the attractive properties of polyisobutylene (PIB) available only by carbocationic polymerization, coupling this hydrophobic, thermally, oxidatively, and hydrolytically stable polymer with a low Tg to a variety of other chain segments is expected to result in new useful products. For instance, methacrylate-telechelic PIB (MA-PIB-MA) obtained by LCCP and subsequent chain end derivatization has been successfully used to synthesize novel amphiphilic networks by radical copolymerization of MA-PIB-MA with a variety of monomers, such as N,N-dimethylacrylamide and 2-trimethylsilyloxyethyl methacrylate, a protected 2-hydroxyethyl methacrylate... 

Other novel mixed polymer systems have included glycosaminoglycans (GAGs) modified with multiblock copolymers to form self-assembling, crosslinker free hydrogels. For example, aminooxy pluronic derivatives were coupled with HA to give amphiphilic hydrogels with the ability to bind to hydrophobic surfaces (89). 

To measure the antibacterial activities of amphiphilic cationic polynorbornene derivatives, they developed a slightly different method based on optical density (OD). In this method, bacteria were grown in suspensions (Escherichia coli D31 and Bacillus subtilis ATCC 8037 ) of Miieller-Hinton broth (MHB) overnight at 37 °C, diluted with fresh MHB to an OD of 0.1 at 600 nm and further diluted by a factor of 10. This suspension was mixed with different concentrations of freshly prepared polymer solutions in rm-buffered saline (pH 6.5-7.0), by serial dilution in a 96-well plate, and incubated for 6 h at 37 °C. The OD 600 nm was measured for bacteria suspensions that were incubated in the presence of a polymer solution or fm-buffered saline only. After 6 h, the MIC for 90% inhibition of growth was determined. 

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