Amphetamine sulfate

NOTE Rats trained to dircriminate (+)amphetamine sulfate (1.0 mg/kg) from saline administered 15 minuted prior to testing. 

NOTE AMPH-like rats were trained to discriminate 1.0 mg/kg of (+)amphetamine sulfate from saline DOM-like rats were trained to discriminate 1.0 mg/kg of DOM-HCl from saline. 

KEY AMPH=eifect of the traiiiiiig dose. 1 mg/kg. of S(+)amphetamine sulfate S=the effect of... 

Scott, J.P. Lee, C. and Ho, J.E. Effects of fighting, genotype, and amphetamine sulfate on body temperature of mice. J Comp Physiol Psychol 76 349-352, 1971. 

Smith GM and Beecher HK (1959). Amphetamine sulfate and athletic performance 1. 

A similar study has been conducted in which the interaction of d-amphetamine sulfate with spray-dried lactose was investigated [32], Upon storage at elevated temperatures, discoloration of the powder blends was noted, and the new absorption bands characterized. One maximum was noted at 340 nm, and this was attributed to the chemisorption of the amine onto the lactose particles. The other band appeared at 295 nm and was attributed to the new compound ([Pg.47]

Dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine aspartate, and amphetamine sulfate. 

Amphetamine sulfate [60-13-9] Daphnla magna EC50 (24-h) 1.78 Lilius et al., 1995... 

The sensitivity is such that a discernible peak is produced by 0.01 yg of amphetamine in 1 cm3 of urine. Forty-eight hours after the ingestion of 5 mg of amphetamine sulfate, it is still possible to detect the amphetamine in the urine. 

Physicians Desk Reference. Dexedrine (brand of dextro-amphetamine sulfate) and DextroStat (brand of dextro-amphetamine sulfate), PDR Electronic Library. Montvale, NJ Medical Economics, 2001. 

Karpovich PV. Effect of amphetamine sulfate on athletic performance. JAMA 1959 170(5) 558-561. 

Tyler DB. The effect of amphetamine sulfate and some barbiturates on the fatigue produced by prolonged wakefulness. Am J Physiol 1947 150 253-262. 

Figure 7-25 FT Raman spectra of (a) 23% amphetamine sulfate in sorbitol, and (b) pure sorbitol. Computer subtraction gives (c) the predicted spectrum of amphetamine sulfate while (d) shows the actual spectrum recorded for a sample of pure amphetamine sulfate. All spectra had 50 scans, 6 cm"1 resolution, and 200 mW of incident laser power. Scanning time was 3 minutes. (Reproduced with permission from Ref. 15. Copyright 1989 John Wiley Sons, Ltd.)...

Having collected the data, a calibration curve should be plotted. Since amphetamine is frequently synthesized in dirty apparatus in clandestine laboratories, it may not be possible to determine which salt form of the drug is present. The standard is generally supplied as the sulfate form, of the general formula (amphetamine)2 sulfate. This means that for every gram of amphetamine sulfate, 73% will be present as the amphetamine free base. The calibration curve should be plotted as (UV detector) response against concentration of amphetamine free base. Exemplar data are presented in Table 2.6 and Figure 2.7. 

Amphetamine sulfate concentration (mgml ) Amphetamine free base concentration (mgml ) Detector response (AU)"... 

This is necessary in order to convert the amphetamine from the sulfate form of the drug to its free base form, and hence to improve the efficiency of the reaction with carbon disulfide. Such a conversion is achieved by the formation of ammonium sulfate and amphetamine, since the ammonia neutralizes the acid. Since ammonia is a strong base, it reacts with the sulfuric acid irreversibly, thus rendering the re-formation of amphetamine sulfate impossible. 

May work in ADHD patients unresponsive to other stimulants, including pure d-amphetamine sulfate... 

---