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Amorphous Drug-Polymer Blends

Huang J, Wigent RJ, Schwartz JB (2008) Drug-polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend. J Pharm Sci 97 251-262. [Pg.260]

The calculation of this interaction parameter of different substances and the polymer displayed the differences as well as similarities of the studied blends (see Table 16.2). For all classic plasticizers, the Flory-Huggins parameter % was equal to or less than 1.132 when mixed with the polymer. For the crystalline drugs ibuprofen and theophylline, X would read 56.6 and 15.5, respectively, whereas the corresponding amorphous states show an extreme decrease in x reading 1.1 and 7.9. [Pg.250]

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