Ammonium thio cyanates

Faneti/ole (122) is a biological response modifier with significant immunosuppressant activity It can be synthesized by conversion of 2 phen> lethylamine (120) with ammonium thio cyanate to the corresponding thiourea analogue 121 The synthesis of faneli/ole (122) concludes by thiazole nng formation of 121 by reaction with phenacylbromide Thus its synthesis involves use of the classic Hantzsch procedure in which a bromoacetone analogue and an appropriate thio urea denvative are reacted 143]... 

With ferric salts in solution either of these reagents forms the cherry red ferric thio-cyanate and is the basis of qualitative tests for iron and the use of the thio-cyanate as an indicator in volumetric titrations. Potassium thio-cyanate may be prepared by heating potassium cyanide with sulphur or ammonium sulphide. Ammonium thio-cyanate may be prepared by heating together carbon disulphide and ammonia in the presence of alcohol. 

Thio-alcohol (mercaptan) Carbon di-sulphide Thionyl chloride Ammonium thio-cyanate Thio-urea... 

In order to have an idea of the range upto which linear relation is valid, for a typical case of isomerisation reaction between NH4CNS (ammonium thio-cyanate) and thio-urea viz. 

Mesoionic pyrido[2,l- >][1,3]oxazines (54) afforded 4-oxo-4//-pyrido[l,2-a]pyrimidin-l-iumolates (55) and 4//-quinolizin-4-one (56) with phenyl iso(thio)cyanates [78LA1655 79CB1585 82ZN(B)222] and dimethyl acetylenedicarboxylate (79CB1585), respectively. Reaction of 2-cyano-3-methyl-lH,6//-pyridol[l,2-a][3,l]benzoxazine-l,6-dione with ammonium acetate and hydroxylamine, hydrazines, primary aliphatic or aromatic amines, and (thio)ureas gave 5-unsubstituted and 5-substituted 2-cyano-3-methyl-l//,6H-pyrido[l,2-a]quinazoline-l,6-diones (93CCC1953). 

This same substitution of sulphur for oxygen occurs in the case of cyanic acid and its salts, e.g., potassium thio-cyanate and ammonium thiocyanate used as reagents in testing for ferric iron. 

This compound undergoes rearrangement the same as ammonium cyanate and thio-urea is obtained. With a soluble mercuric salt ammonium thiocyanate precipitates mercuric thio-cyanate which on heating swells up into phantastic shapes which are known as Pharaoh s serpents. The alkyl thio-cyanates are known and have been discussed (p. 74). Allyl-thio-cyanate is a constituent of oil of garlic. These... 

Thio-ureas.—As sulphur may replace oxygen in carbon dioxide, alcohol, carbonyl chloride and ammonium cyanate yielding corresponding thio compoundsj so also there are sulphur analogues of urea known as thio-ureas. These need not be considered more than to give the oxygen and sulphur compounds in this relationship. 

AI3-28741 Ammonium diammineletrakis(thiocyanato-N)chromate(l-) Chromate(l-), diammin8tetrakis(thio-cyanato-N)-, ammonium Chromate(l-). diamminetetra-kis(thiocyanato-N)-, ammonium, (OC-6-11)- EINECS 237-003-3 Reinecke salt. Produced when ammonium cyanate is melted and ammonium bichromate added used as a precipitating agent for organic bases and amino acids and as a reagent for mercury, mp = 270 (dec). 

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