Ammonium persulfate on silica

The quest for a solvent-free deprotection procedure has led to the use of relatively benign reagent, ammonium persulfate on silica, for regeneration of carbonyl compounds (Scheme 6.10) [48]. Neat oximes are simply mixed with solid supported reagent and the contents are irradiated in a MW oven to regenerate free aldehydes or ketones in a process that is applicable to both, aldoximes and ketoximes. The critical role of surface needs to be emphasized since the same reagent supported on clay surface delivers predominantly the Beckmann rearrangement products, the amides [49]. 

The search for a solvent-free deprotection procedure has led to the use of the relatively benign reagent ammonium persulfate on silica, for regeneration of carbonyl compounds (Scheme 2.2-29) [93]. Neat oximes are simply admixed with the so-... 

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See also in sourсe #XX -- [ ]

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