Aminopyrrolidine Catalysts

Addition of Aldehydes to Nitroolefins and Alkylidene Malonates 2.3.4.1 Aminopyrrolidine Catalysts 

The diphenylprolinol silyl ether 45a catalyst was developed by the Hayashfs group for the addition of a-unbranched aldehydes to aryl and alkyl substituted nitroolefins [35]. This catalyst, as well as the perfluoroalkyl derivative 45b [36], 

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Polyaniline-supported Co(II) catalyst 41 was used to catalyze the epoxidation of various alkenes under oxygen atmosphere at ambient temperature.61 63 One report61 described a synthesis of a-hydroxy- 3-aminopyrrolidine amides as potential HIV protease inhibitors (Scheme 1). In this synthesis, catalyst 41 also mediated epoxide ring opening of the epoxide intermediate by an aniline to afford the desired product. 

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