4-Aminopteroylglutamic acid

Common Name 4-Amino-4-deoxyfolic acid 4-Aminofolsaure 4-Amino-PGA Aminopterin 4-Aminopteroylglutamic acid 4-Aminopteroylglutaminsaure Antifolic acid Antifolsaure... 

SYNS 4-AMINO-4-DEOXYPTEROYLGLUTAMATE 4-AMINO-PGA AMINOPTERIN 4-AMINOPTEROYLGLUTAMIC ACID APGA ENT 26,079 FOLIC ACID, 4-AMINO- NSC-739... 

PICOUNIUM CHLORIDE see AOD175 AMINOPTERIDINE see AMG750 AMINOPTERIN see AMG750 4-AMINOPTEROYLGLUTAMIC ACID see AMG750 6-A NOPURINE see AEHOOO 6-AMINO-lH-PURINE see AEHOOO 6-AMINO-3H-PURINE see AEHOOO 6-AMINO-9H-PURINE see AEHOOO... 

Farber S et al. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroylglutamic acid (aminopterin). N EnglJ Med 1948 238 787-793. 

AIC also accumulated when E. coli was grown in the presence of aminopterin (4-aminopteroylglutamic acid), a folic acid antagonist. Since addition of aminopterin or p-aminobenzoic acid antimetabolites e.g., sulfonamides) results in the accumulation of AIC, it is presumed that the latter act by creating a folic acid deficiency. Thus, folic acid or a related derivative, and not p-aminobenzoic acid, may be directly concerned with purine synthesis. This is in agreement with Woods hypothesis that the primary action of sulfonamides is the inhibition of folic acid formation, and that purine synthesis is a secondary event in which p-aminobenzoic acid participates only indirectly. ... 

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