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Aminopalladation alkyne amination

Amines undergo aminopalladation to alkynes. The intramolecular addition of amines to alkynes yields cyclic imines. The 3-alkynylamine 273 was cyclized to the 1-pyrroline 274, and the 5-alkynylamine 275 was converted into the 2,3,4,5-tetrahydropyridine 276[137]. Cyclization of o-(l-hexynyl)aniline (277)... [Pg.502]

Formation of the pyrrole 278 from l-amino-3-alkyn-2-ol 276 is catalyzed by PdCl2. The reaction can be understood as aminopalladation to generate 277, followed by protonolysis and dehydration [116]. Indoles are prepared from o-alkynyl aromatic amines. The required alkynyl amine 279 is prepared from o-iodoacetanilide. Aminopalladation of 279 and protonolysis affords 280 [117]. [Pg.63]


See other pages where Aminopalladation alkyne amination is mentioned: [Pg.4]    [Pg.726]   


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