Aminolysis of Extranuclear Halogenoquinoxalines

Extranuclear halogenoquinoxalines undergo aminolysis satisfactorily by primary, secondary, or tertiary amines direct aminolysis by ammonia (ammonolysis) [Pg.175]

6- Bromo-8-bromomethyl-2,3-dimethoxyquinoxaline (238, R = Br) gave 5-azi-domethyl-7-bromo-2,3-dimethoxyquinoxaline (241) (NaN3, PhMe-H20, 55°C, 16 h 65%) and thence 5-aminomethyl-7-bromo-2,3-dimethoxyqui-noxaline (242) (Raney Ni, THF, 20°C, 15 h 63%). [Pg.176]

2-Bromomethyl-3-methylquinoxaline (243, R = Br) gave 2-methyl-3-(methyl-aminomethyl)quinoxaline (243, R = NHMe) (MeNH2, EtOH, 0°C, 3h 90%). [Pg.176]

2-Bromomethyl-6,7-dichloro-3-phenylthioquinoxaline 1,4-dioxide (245, Q = SPh, R = Br) gave 6,7-dichloro-2-(2-hydroxyethylamino)-3-(2-hydroxyethy-lamino)methylquinoxaline 1,4-dioxide (245, Q = R = NHCH2CH2OH) (H2NCH2CH2OH, CHCI3, 20°C, 4 days 62% note concomitant aminolysis [Pg.177]

2-Bromomethyl-6,7-dimethyl-3-phenylquinoxaline (246, R = Br) gave 2-dimethyl-aminomethyl-6,7-dimethyl-3-phenylquinoxaline (246, R = NMe2) (Me2NH, [Pg.177]

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