5-Aminolevulinic acid adverse effects

ALAD = aminolevulinic acid dehydratase d = day(s) F = female Gd = gestational day Hemato = hematological hr = hour(s) LDH = lactatate dehydrogenase LOAEL = lowest-observable-adverse-effect level M = male NOAEL = no-observable-adverse-effect level Resp = respiratory wk = week(s). 

Barbiturates reduce hepatic blood flow and glomerular filtration rate, but these drugs produce no adverse effects on hepatic or renal function. Barbiturates can exacerbate acute intermittent porphyria by inducing the production of hepatic ct -aminolevulinic acid (ALA) synthase (see Chapter 22). On rare occasions, thiopental has precipitated porphyric crisis when used as an induction agent in susceptible patients. 

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