Aminolead compounds

The regioselective ring-opening of epoxides 34 (R1 = Me, vinyl, Ph etc.) with aminolead compounds R23 PbNEt2, prepared from lithium diethylamide and R23 PbBr, gives good yields of the amino alcohols 3567. 

Aminolead compounds of the simplest types, R3PbNR2 with, e.g. R = Me, Et have recently been synthesized. Using the procedure which has been successful for the synthesis of aminotin compounds 126) these compounds were obtained without difficulty 152, 196) from lithium dialkylamides and organolead halogenides (Table XIII). 

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