2-Aminoheptanedioic acid

Aminopimelic acid Apm 2-Aminoheptanedioic acid HOOC (CH2)ta-CHlNH2)-COOH... 

Following Scheme 4, L-a-aminosuberic acid can be obtained from iV-tosyI -L-gl utamic acid (5, n=2), upon protection of the a-carboxy and tosylamino groups as an oxazolidone 6, by extension of the side chain with the Amdt-Eistert method via the diazo ketone 7 by one methylene moiety in each cycle to produce in subsequent steps the L-a-aminoadipic acid [(5)-2-aminohexanedioic acid, 8, n = 2], L-a-aminopimelic acid [(5)-2-aminoheptanedioic acid, 8, n = 3] and finally L-a-aminosuberic acid [(5)-2-aminooctanedioic acid, 8, n = 4]J22 Treatment with HBr in AcOH was the method of choice for the acidolytic hydrolysis of the tosyl group. 23 ... 

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