Aminoglycoside antibiotics proximal renal tubular

Another class of catamphiphilic drugs with high toxic potential is the aminoglycosides. Their nephrotoxicity is manifested by lethal injury to the proximal tubular cells by means of the induction of renal cortical lysosomal phospholipidosis. The toxic effect involves three steps the uptake of the antibiotics into the cells, the intralysoso-mal lipid storage, and, finally, cell necrosis. The aminoglycosides are highly water... 

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