Aminoglycoside and Aminocyclitol Antibiotics

1 Aminoglycoside and Aminocyclitol Antibiotics Reviews have appeared on new semi-synthetic aminoglycoside antibiotics, with particular reference to habekacin and polydeoxy- 

New compounds reported include inosamycin, a complex produced by S.hyRroscopicus, which is related to neomycin and paromomycin, but containing 2-deoxy-scyllo-inosamine (1) instead of 2-deoxystrept- 

A synthesis of the pseudodisaccharide 3-0-methylsporaricin A has been reported, coupling suitably protected derivatives of the di-amino sugar 1-acetate and the diaminocyclitol using trimethylsilyl triflate,  

A synthesis of 6-deoxy-6-hydroxyamino- -D-glucopyranoside from the corresponding 6-aminosugar by the sequence of oxidation with hydrogen peroxide - sodium tungstate to the oxime followed by cyanoborohydride reduction was copied in a synthesis of the pseudo-trisaccharides 6 -N-hydroxykanamycin A and 6 -N-hydroxydibekacin from the corresponding parent antibiotics, but the products were 

A number of 4 -epi-amikacin derivatives (0H,F,N2) have been synthesized, which should be less sensitive to enzymatic deactivation, but all were much less active than the parent. 

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