Aminodeoxychorismate lyase

Figure 2 Biosynthesis of foiates. a, GTP cyclohydrolase I b, dihydroneopterin epimerase c, nudix hydrolase d, phosphatase e, dihydroneopterin aldolase f, hydroxymethyidihydropterin pyrophosphokinase g, dihydropteroate synthase h, dihydrofolate synthetase I, dihydrofolate reductase j, folylpolyglutamate synthetase k, aminodeoxychorismate synthase I, aminodeoxychorismate lyase. 7, 7,8-dihydro-D-neopterin 3 -triphosphate 8, 7,8-dihydro-L-monapterin 3 -triphosphate 9, 7,8-dihydro-D-neopterin 3 -monophosphate 10, 7,8-dihydro-D-neopterin 11, glycolaldehyde ...

Meanwhile, as shown in Scheme 12.120, chorismate is converted to 4-amino-4-deoxychorismate (aminodeoxychorismate synthase, EC 2.6.1.85) and thence to 4-aminobenzoate and pyruvate (aminodeoxychorismate lyase, EC 4.1.3.38). 

Scheme 12.120. A representation of the conversion of chorismate to 4-amino-4-deoxychorismate (aminodeoxychorismate synthase, EC 2.6.1.85) and thence to 4-aminobenzoate and pyruvate (aminodeoxychorismate lyase, EC 4.1.3.38). The attractive common bicyclic lactone intermediate shown, although not required, is based on a suggestion of Walsh, C. T Liu, X Rusnak, E Sakaitani, M. Chem. Rev., 1990,90,1105. EC numbers and some graphic materials provided in this scheme have been taken from appropriate links in a URL starting with http //www.chem.qmul.ac.uk/iubmb/enzyme/.

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