Aminocarbafuranoses

According to the classical sugar classification, this Chapter is subdivided into five sections carbaaldofuranoses (2.1), carbaketofuranoses (2.2), unsaturated carbafuranoses (2.3), aminocarbafuranoses (2.4) and thiocarbafuranoses (2.5). 

Aminocarbafuranoses have been widely utilized as building blocks for the construction of carbocyclic nucleosides whose heterocyclic base is forged... 

In a structure-based drug-discovery programme in the field of influenza virus neuraminidase inhibitors, researchers at BioCryst Pharmaceuticals discovered aminocarbafuranose sialyl mimetic 89 as a very potent candidate against influenza A and B viruses [17]. To arrive at this highly substituted compound in a non-racemic format, the viable route of Scheme 14 was executed. 

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